Amyloid-Beta 3 Antibody

Product Specifications

Background

Pyro-glutamic acid truncated amyloid beta 3-40/42 may have a greater propensity to aggregate under physiological conditions. In addition, this pyro E modification has been implicated as the molecular species responsible for seeding larger oligomers of amyloid-β . Pyro-glutamic acid truncated amyloid beta 3-40/42’s exact involvement in the pathophysiology of Alzheimer’s disease has not been established.

NCBI Gene ID

351

Swiss Prot

P05067

Accession Number

P05067

Host

Rabbit

Reactivity

Human, Bovine, Sheep, Non-Human Primate

Immunogen

A synthetic peptide corresponding to the N-terminus 3-pyro E start point.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Affinity Purified

Concentration

Batch dependent

Modification

None

Shipping Conditions

Dry Ice

Fragment

IgG

Applications Notes

ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing)

Symbol

APP

NCBI Official Name

Amyloid beta (A4) precursor protein

NCBI Organism

Homo sapiens

Background Reference 01

Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G, Demuth HU. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro) . Biochemistry. 2006 Oct 17;45 (41) :12393-9

Background Reference 02

He W, Barrow CJ. The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. Biochemistry. 1999 Aug 17;38 (33) :10871-7

Background Reference 03

Alzheimer research forum review see http://www.alzforum.org/new/detailprint.asp?id=1577

Background Reference 04

Youssef I, Florent-Béchard S, Malaplate-Armand C, Koziel V, Bihain B, Olivier JL, Leininger-Muller B, Kriem B, Oster T, Pillot T., N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis. Neurobiology of Aging 29 (2008) 1319-1333