Amyloid-Beta 11 Antibody

Product Specifications

Background

Pyroglutamic acid truncated amyloid beta 11-40/42 may have a greater propensity to aggregate under physiological conditions. In addition, this pyrE modification has been implicated as the molecular species responsible for seeding larger oligomers of amyloid-β . Pyroglutamic acid truncated amyloid beta 11-40/42’s exact involvement in the pathophysiology of Alzheimer’s disease has not been established

NCBI Gene ID

351

Swiss Prot

P05067

Accession Number

P05067

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to the N-terminus 11-pyro E start point.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Affinity Purified

Concentration

Batch dependent

Modification

None

Shipping Conditions

Room Temp

Fragment

IgG

Applications Notes

ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing)

Symbol

APP

NCBI Official Name

Amyloid beta (A4) precursor protein

NCBI Organism

Homo sapiens

Background Reference 01

Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G, Demuth HU. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro) . Biochemistry. 2006 Oct 17;45 (41) :12393-9

Background Reference 02

He W, Barrow CJ. The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. Biochemistry. 1999 Aug 17;38 (33) :10871-7

Background Reference 03

Alzheimer research forum review see http://www.alzforum.org/new/detailprint.asp?id=1577

Background Reference 04

Youssef I, Florent-Béchard S, Malaplate-Armand C, Koziel V, Bihain B, Olivier JL, Leininger-Muller B, Kriem B, Oster T, Pillot T., N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis. Neurobiology of Aging 29 (2008) 1319-1333