Beta-Actin Antibody (biotin)

Product Specifications

Background

Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. Beta actin is one of six different actin isoforms which have been identified. Like GAPDH, beta-Actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

NCBI Gene ID

Swiss Prot

P60709

Accession Number

AAH02409

Host

Rabbit

Reactivity

Human, Mouse, Rat, Rabbit, Chicken, Drosophila

Immunogen

Biotin-Beta-Actin antibody was raised against a synthetic peptide containing 16 amino acids near the amino terminus of beta-actin.

Clonality

Polyclonal

Conjugation

Biotin

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

Biotin-Beta-Actin antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

Biotin-Beta-Actin antibody is supplied in PBS containing 1% BSA and 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Biotin-Beta-Actin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

Biotin-Beta-Actin antibody is human, mouse, rat, rabbit, chicken, and drosophila reactive.

Symbol

ACTB

NCBI Official Name

Actin, beta

NCBI Organism

Homo sapiens

Background Reference 01

Lambrechts A, Van Troys, M and Ampe C. The actin cytoskeleton in normal and pathological cell motility. Int. J. Biochem. Cell Biol. 2004; 36:1890-909.