NLRP1/NALP1 Antibody
Product Specifications
Background
NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.
NCBI Gene ID
22861
Swiss Prot
Q9C000
Accession Number
11096303
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) at the N-terminus of human NLRP1/NALP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity, Inflammasomes
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=36-322
Specificity
Recognizes human NLRP1/NALP1. Does not cross-react with mouse NLRP1/NALP1.
Applications Notes
Western Blot: (1:1,000) .
Symbol
NLRP1
NCBI Official Name
NLR family, pyrin domain containing 1
NCBI Organism
Homo sapiens
Other Product Names
NACHT-, LRR- and PYD-containing Protein 1; NLRP1; Caspase Recruitment Domain-containing Protein 7; Death Effector Filament-forming Ced-4-like Apoptosis Protein; Nucleotide-binding Domain and Caspase Recruitment Domain
Tested Applications
WB
Protein ID
AAG30288
Physical Properties
Liquid
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