What is the catalog number for Caspase-11 Antibody [4E11]?

The catalog number for Caspase-11 Antibody [4E11] is 36-183.

What sizes are available for Caspase-11 Antibody [4E11]?

Caspase-11 Antibody [4E11] is available in the following size(s): 100 µg.

Is Caspase-11 Antibody [4E11] in stock?

Caspase-11 Antibody [4E11] is currently made to order / not held in immediate stock. Contact us for lead time.

Caspase-11 Antibody [4E11]

Product Specifications

Background

Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

NCBI Gene ID

12363

Swiss Prot

P70343

Accession Number

341940314

Host

Rat

Reactivity

Mouse, Rat

Immunogen

Recombinant mouse caspase-11 (p20 fragment) .

Clonality

Monoclonal

Clone

4E11

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Innate Immunity, Inflammasomes

Purification

>95% (SDS-PAGE)

Concentration

1 mg/ml

Buffer

Liquid. In PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG1, kappa

Specificity

Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.

Applications Notes

ELISA: (recombinant protein) . Flow Cytometry: (overexpressed in cell lines) . Immunoprecipitation: (1-5ug/ml) . Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.