Caspase-11 Antibody [4E11]
Product Specifications
Background
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.
NCBI Gene ID
12363
Swiss Prot
P70343
Accession Number
341940314
Host
Rat
Reactivity
Mouse, Rat
Immunogen
Recombinant mouse caspase-11 (p20 fragment) .
Clonality
Monoclonal
Clone
4E11
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Innate Immunity, Inflammasomes
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=36-183
Fragment
IgG1, kappa
Specificity
Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.
Applications Notes
ELISA: (recombinant protein) . Flow Cytometry: (overexpressed in cell lines) . Immunoprecipitation: (1-5ug/ml) . Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.
Symbol
Casp4
NCBI Official Name
Caspase 4, apoptosis-related cysteine peptidase
NCBI Organism
Mus musculus
Other Product Names
Caspase-11 (mouse) ; Protease ICH-3 (mouse)
Tested Applications
ELISA, Flow, IP, WB
Protein ID
P70343
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
