Bmf Antibody [17A9]
Product Specifications
Background
Bmf (Bcl-2-modifying factor) belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homo-dimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bmf contains a single Bcl-2 homology domain 3 (BH3), and has been shown to interact with other Bcl-2 proteins and functions as an apoptotic activator. Two different start sites can give rise to two proteins of 25 or 30 kDa. It is found to be sequestered to myosin V motors by its association with dynein light chain 2 (DLC2), which may be important for sensing intracellular damage and triggering apoptosis.
NCBI Gene ID
171543
Swiss Prot
Q91ZE9
Accession Number
56748562
Host
Rat
Reactivity
Mouse, Rat
Immunogen
Recombinant full length mouse Bmf and synthetic peptides corresponding to aa 13-27 and aa 112-126 of mouse Bmf.
Clonality
Monoclonal
Clone
17A9
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Immunology
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=36-174
Fragment
IgG2a, kappa
Specificity
Recognizes an epitope within the peptide sequence aa 13-27 of mouse and rat Bmf. Detects bands of ~25kDa and ~30kDa by Western blot, corresponding to endogenous Bmf and BmfL. Does not cross-react with human Bmf.
Applications Notes
Flow Cytometry: (overexpressed in cell lines) . Immunoprecipitation: (1-5ug/ml) . Western Blot: (1-2ug/ml) .
Symbol
Bmf
NCBI Official Name
BCL2 modifying factor
NCBI Organism
Mus musculus
Other Product Names
Bcl-2-modifying Factor
Tested Applications
ELISA, Flow, ICC, IHC, IP, WB
Protein ID
Q91ZE9
Physical Properties
Liquid
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