FLIP Antibody [NF6]
Product Specifications
Background
FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.
NCBI Gene ID
8837
Swiss Prot
O15519
Accession Number
2253679
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human FLIP (aa 1-480) .
Clonality
Monoclonal
Clone
NF6
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1
Specificity
Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP.
Applications Notes
Immunohistochemistry (paraffin sections) . Western Blot (1:1000) .
Symbol
CFLAR
NCBI Official Name
CASP8 and FADD-like apoptosis regulator
NCBI Organism
Homo sapiens
Other Product Names
I-FLICE; CLARP; CASPER; Usurpin, CASH; FLAME-1
Tested Applications
ICC, IHC, WB
Protein ID
AAC51622
Physical Properties
Liquid
Frequently Asked Questions
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