BTLA Antibody [6F4]

Product Specifications

Background

B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

NCBI Gene ID

151888

Swiss Prot

Q7Z6A9

Accession Number

145580621

Host

Rat

Reactivity

Human

Immunogen

Ectodomain of human BTLA fused to human IgG Fc.

Clonality

Monoclonal

Clone

6F4

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology, Innate Immunity

Purification

>95% (SDS-PAGE)

Concentration

1 mg/ml

Buffer

Liquid. In PBS containing 10% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG1

Specificity

Recognizes human BTLA.

Applications Notes

Immunohistochemistry: (frozen sections) .

Symbol

BTLA

NCBI Official Name

B and T lymphocyte associated

NCBI Organism

Homo sapiens

Other Product Names

B and T Lymphocyte Associated; Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3