NLRP6/NALP6 Antibody [Clint-1]

The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL) -1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

NACHT-, LRR and PYD Domains-containing Protein 6; Nod-like Receptor Pyrin Domain-containing Protein 6; NLRP6; Angiotensin II/Vasopressin Receptor; PYRIN-containing APAF1-like Protein 5; NALP6