NLRP6/NALP6 Antibody [Clint-1]

Product Specifications

Background

The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL) -1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

NCBI Gene ID

171389

Swiss Prot

P59044

Accession Number

21264320

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human NLRP6 (NACHT domain) .

Clonality

Monoclonal

Clone

Clint-1

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Innate Immunity, Innate Immunity

Purification

>95% (SDS-PAGE)

Concentration

1 mg/ml

Buffer

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG1, kappa

Specificity

Recognizes human NLRP6.

Applications Notes

Western Blot: (1ug/ml) . Immunohistochemistry: (frozen sections) (1:500) .

Symbol

NLRP6

NCBI Official Name

NLR family, pyrin domain containing 6

NCBI Organism

Homo sapiens

Other Product Names

NACHT-, LRR and PYD Domains-containing Protein 6; Nod-like Receptor Pyrin Domain-containing Protein 6; NLRP6; Angiotensin II/Vasopressin Receptor; PYRIN-containing APAF1-like Protein 5; NALP6