PIDD Antibody [Lise-1]
Product Specifications
Background
PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
NCBI Gene ID
57913
Swiss Prot
Q9ERV7
Accession Number
81868332
Host
Mouse
Reactivity
Mouse
Immunogen
Mouse PIDD (Death Domain) .
Clonality
Monoclonal
Clone
Lise-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG2b, kappa
Specificity
Recognizes mouse PIDD.
Applications Notes
Western Blot: (1:1,000) .
Symbol
Pidd1
NCBI Official Name
P53 induced death domain protein 1
NCBI Organism
Mus musculus
Other Product Names
P53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd
Tested Applications
WB
Protein ID
Q9ERV7
Physical Properties
Liquid
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