CD40 Antibody [FGK45]
Product Specifications
Background
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
NCBI Gene ID
21939
Swiss Prot
P27512
Accession Number
172046819
Host
Rat
Reactivity
Mouse
Immunogen
Recombinant mouse CD40 fusion protein.
Clonality
Monoclonal
Clone
FGK45
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Cancer, Immunology, Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG2a
Specificity
Recognizes mouse CD40.
Applications Notes
Functional Application: Activates B and NK cells in vivo and in vitro. For in vivo studies use the preservative free antibody.
Symbol
Cd40
NCBI Official Name
CD40 antigen
NCBI Organism
Mus musculus
Other Product Names
Tumor Necrosis Factor Receptor Superfamily Member 5; CD40L Receptor
Tested Applications
Flow, Functional Assays
Protein ID
P27512
Physical Properties
Liquid
Curated Selection
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