TRAIL-R2 Antibody [TR2.21]

Product Specifications

Background

TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

NCBI Gene ID

8795

Swiss Prot

O14763

Accession Number

2338419

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human TRAIL-R2 (DR5) .

Clonality

Monoclonal

Clone

TR2.21

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology

Purification

>95% (SDS-PAGE)

Concentration

1 mg/ml

Buffer

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG1

Specificity

Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

Applications Notes

Immunohistochemistry: (paraffin sections) (20ug/ml) . Western Blot: (1ug/ml) . Optimal conditions must be determined individually for each application.