TRAIL Antibody [HS501]
Product Specifications
Background
TNF-related apoptosis-inducing ligand (TRAIL; Apo2L; CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B) . Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC) . .
NCBI Gene ID
8743
Swiss Prot
P50591
Accession Number
4507593
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human TRAIL.
Clonality
Monoclonal
Clone
HS501
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1
Specificity
Recognizes human TRAIL.
Applications Notes
Western Blot: (1:1000) .
Symbol
TNFSF10
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 10
NCBI Organism
Homo sapiens
Other Product Names
Apo-2L; TNFSF10; CD253
Tested Applications
WB
Protein ID
NP_003801
Physical Properties
Liquid
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