TRAIL-R2 Antibody [HS201] (biotin)

Product Specifications

Background

TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

NCBI Gene ID

8795

Swiss Prot

O14763

Accession Number

2338419

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human TRAIL-R2 (DR5) .

Clonality

Monoclonal

Clone

HS201

Conjugation

Biotin

Type

Primary Antibodies, Functional Antibodies

Field of Research

Apoptosis, Cancer, Immunology

Purification

>95% (SDS-PAGE)

Concentration

0.5 mg/ml

Buffer

Liquid. In PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=36-130

Fragment

IgG1

Specificity

Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

Applications Notes

Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution) . Immunohistochemistry: (paraffin sections, 15ug/ml) .

Symbol

TNFRSF10B

NCBI Official Name

Tumor necrosis factor receptor superfamily, member 10b

NCBI Organism

Homo sapiens

Other Product Names

TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262

Tested Applications

Flow, Functional Assays, ICC, IHC, IP

Protein ID

AF012535

Physical Properties

Liquid

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TRAIL-R2 Antibody [HS201] (biotin)

Product Specifications

Background

NCBI Gene ID

Swiss Prot

Accession Number

Host

Reactivity

Immunogen

Clonality

Clone

Conjugation

Type

Field of Research

Purification

Concentration

Buffer

Modification

Shipping Conditions

Storage Conditions

Product Datasheet

Fragment

Specificity

Applications Notes

Symbol

NCBI Official Name

NCBI Organism

Other Product Names

Tested Applications

Protein ID

Physical Properties

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