TRAIL-R2 Antibody [HS201] (preservative free)
Product Specifications
Background
TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
NCBI Gene ID
8795
Swiss Prot
O14763
Accession Number
2338419
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human TRAIL-R2 (DR5) .
Clonality
Monoclonal
Clone
HS201
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Cancer, Immunology
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol. Preservative free formulation.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1
Specificity
Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.
Applications Notes
Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution) .
Symbol
TNFRSF10B
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 10b
NCBI Organism
Homo sapiens
Other Product Names
TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262
Tested Applications
Flow, Functional Assays, ICC, IP
Protein ID
AF012535
Physical Properties
Liquid
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