TRAIL-R2 Antibody [HS201]

Product Specifications

Background

TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

NCBI Gene ID

8795

Swiss Prot

O14763

Accession Number

2338419

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human TRAIL-R2 (DR5) .

Clonality

Monoclonal

Clone

HS201

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Cancer, Immunology

Purification

>95% (SDS-PAGE)

Concentration

1 mg/ml

Buffer

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG1

Specificity

Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

Applications Notes

Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution) . Immunohistochemistry: (paraffin sections, 15ug/ml) .

Symbol

TNFRSF10B

NCBI Official Name

Tumor necrosis factor receptor superfamily, member 10b

NCBI Organism

Homo sapiens

Other Product Names

TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262

Tested Applications

Flow, Functional Assays, ICC, IHC, IP

Protein ID

AF012535

Physical Properties

Liquid

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