TRAIL-R1 Antibody [HS101]
Product Specifications
Background
TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
NCBI Gene ID
8797
Swiss Prot
O00220
Accession Number
1945072
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human TRAIL-R1 (DR4) .
Clonality
Monoclonal
Clone
HS101
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Apoptosis, Cancer, Immunology
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1
Specificity
Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4.
Applications Notes
Functional Application: Inhibition (blocks TRAIL-R1 mediated killing if applied in solution) .
Symbol
TNFRSF10A
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 10a
NCBI Organism
Homo sapiens
Other Product Names
TRAIL Receptor 1; DR4; APO2; TNFRSF10A; CD261
Tested Applications
Flow, Functional Assays, ICC, IP
Protein ID
AAC51226
Physical Properties
Liquid
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