BAFF Antibody [4.62]
Product Specifications
Background
BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE) . Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL) .
NCBI Gene ID
10673
Swiss Prot
Q9Y275
Accession Number
5730097
Host
Rat
Reactivity
Human
Immunogen
HA-tagged human BAFF.
Clonality
Monoclonal
Clone
4.62
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology, Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG2a
Specificity
Recognizes human BAFF.
Applications Notes
ELISA: (as a detection antibody) . Functional Application: Inhibition of human BAFF binding. Immunoprecipitation: (1:200) .
Symbol
TNFSF13B
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 13b
NCBI Organism
Homo sapiens
Other Product Names
BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B
Tested Applications
ELISA, Functional Assays, IP
Protein ID
NP_006564
Physical Properties
Liquid
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