MDA5 Antibody [Hely-1]
Product Specifications
Background
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
NCBI Gene ID
64135
Swiss Prot
Q9BYX4
Accession Number
27886568
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human MDA5 (aa 78-555) .
Clonality
Monoclonal
Clone
Hely-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1
Specificity
Recognizes human MDA5.
Applications Notes
Immunoprecipitation: (1:100) . Western Blot: (1:1‘000) .
Symbol
IFIH1
NCBI Official Name
Interferon induced with helicase C domain 1
NCBI Organism
Homo sapiens
Other Product Names
Helicard; Melanoma Differentiation-associated Gene 5
Tested Applications
ELISA, IP, WB
Protein ID
NP_071451
Physical Properties
Liquid
Curated Selection
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