LAG-3 Antibody [17B4]

Product Specifications

Background

Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

NCBI Gene ID

3902

Swiss Prot

P18627

Accession Number

251757512

Host

Mouse

Reactivity

Human

Immunogen

Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.

Clonality

Monoclonal

Clone

17B4

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology, Innate Immunity

Purification

>95% (SDS-PAGE)

Concentration

1 mg/ml

Buffer

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG1

Specificity

Recognizes human LAG-3.

Applications Notes

Immunohistochemistry: (EM) . Immunoprecipitation: (1-2ug/ml) . Western Blot: (1-5ug/ml) . Optimal conditions must be determined individually for each application.