LAG-3 Antibody [11E3]
Product Specifications
Background
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
NCBI Gene ID
3902
Swiss Prot
P18627
Accession Number
251757512
Host
Mouse
Reactivity
Human, Monkey
Immunogen
Recombinant human LAG-3.
Clonality
Monoclonal
Clone
11E3
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology, Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
0.5 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1
Specificity
Recognizes human and monkey LAG-3.
Applications Notes
ELISA: (as a capture antibody) . Functional Application: Inhibition. Immunohistochemistry: (frozen sections) . Immunoprecipitation: (10ug/ml) . Western Blot: (5ug/ml) .
Symbol
LAG3
NCBI Official Name
Lymphocyte activating 3
NCBI Organism
Homo sapiens
Other Product Names
Lymphocyte Activation Gene-3; FDC Protein; CD223
Tested Applications
ELISA, Functional Assays, ICC, IHC, IP, WB
Protein ID
P18627
Physical Properties
Liquid
Frequently Asked Questions
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