RIG-I Antibody [Alme-1] (biotin)
Product Specifications
Background
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
NCBI Gene ID
23586
Swiss Prot
O95786
Accession Number
81170421
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Recombinant human RIG-I (aa 201-713) .
Clonality
Monoclonal
Clone
Alme-1
Conjugation
Biotin
Type
Primary Antibodies
Field of Research
Immunology, Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
0.5 mg/ml
Buffer
Liquid. In PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1
Specificity
Recognizes human and mouse RIG-I.
Applications Notes
Immunohistochemistry: (paraffin sections) . Immunoprecipitation: (1:200) . Western blot: (1:1,000) .
Symbol
DDX58
NCBI Official Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
NCBI Organism
Homo sapiens
Other Product Names
RIG-1; Retinoic Acid-inducible Gene 1 Protein; DEAD-box Protein 58; Probable ATP-dependent RNA Helicase DDX58
Tested Applications
IHC, IP, WB
Protein ID
O95786
Physical Properties
Liquid
Curated Selection
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