LTbetaR Antibody [4H8 WH2]
Product Specifications
Background
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
NCBI Gene ID
17000
Swiss Prot
P50284
Accession Number
1729988
Host
Rat
Reactivity
Mouse
Immunogen
Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221) .
Clonality
Monoclonal
Clone
4H8 WH2
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology, Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=36-100
Fragment
IgG2a
Specificity
Recognizes mouse LTbetaR.
Applications Notes
Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.
Symbol
Ltbr
NCBI Official Name
Lymphotoxin B receptor
NCBI Organism
Mus musculus
Other Product Names
Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
Tested Applications
Flow, Functional Assays
Protein ID
P50284
Physical Properties
Liquid
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