LTbetaR Antibody [4H8 WH2]

Product Specifications

Background

The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

NCBI Gene ID

17000

Swiss Prot

P50284

Accession Number

1729988

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221) .

Clonality

Monoclonal

Clone

4H8 WH2

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology, Innate Immunity

Purification

>95% (SDS-PAGE)

Concentration

1 mg/ml

Buffer

Liquid. In PBS containing 10% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG2a

Specificity

Recognizes mouse LTbetaR.

Applications Notes

Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.

Symbol

Ltbr

NCBI Official Name

Lymphotoxin B receptor

NCBI Organism

Mus musculus

Other Product Names

Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3