NLRP3/NALP3 Antibody [Cryo-1]
Product Specifications
Background
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL) -1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA) .
NCBI Gene ID
216799
Swiss Prot
Q8R4B8
Accession Number
29427844
Host
Mouse
Reactivity
Mouse
Immunogen
Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93) .
Clonality
Monoclonal
Clone
Cryo-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity, Inflammasomes
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG2b
Specificity
Recognizes mouse NLRP3/NALP3.
Applications Notes
Western Blot (see online protocol) : (1ug/ml) .
Symbol
Nlrp3
NCBI Official Name
NLR family, pyrin domain containing 3
NCBI Organism
Mus musculus
Other Product Names
NACHT-, LRR- and PYD-containing Protein 3; NLRP3; Cryopyrin; Cold Autoinflammatory Syndrome 1 Protein
Tested Applications
WB
Protein ID
Q8R4B8
Physical Properties
Liquid
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