NS5B Antibody [5B-12B7]
Product Specifications
Background
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Host
Mouse
Reactivity
HCV
Immunogen
Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
Clonality
Monoclonal
Clone
5B-12B7
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG2a
Specificity
Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392) . Does not react with genotype 2.
Applications Notes
Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.
Other Product Names
Nonstructural Protein 5B
Tested Applications
Functional Assays, ICC, IP
Physical Properties
Liquid
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV779040 1.0 µg DNA
RPL26P34 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)
Sign In for Pricing
View Details 
GTR15292189 1 Vial
Lentiviral mouse Otub2 shRNA (UAS) - Lentiviral mouse Otub2 shRNA (UAS, RFP) plasmid
Sign In for Pricing
View Details