CTRP6 Antibody [256-E]

Product Specifications

Background

CTRP6 mediates the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in skeletal muscle cells, subsequently mediating glycogen accumulation and fatty acid oxidation. It induces the expression of the potent anti-inflammatory cytokine IL-10 in macrophages. CTRP6 may be a potential serum marker for hepatocellular carcinoma, contributing to tumor angiogenesis by activating the Akt pathway. CTRP6 was also shown to be associated with obesity, type 1 diabetes mellitus (T1D), vitiligo (depigmentation of the skin) and ASFV (African Swine Fever Virus) . CTRP6 forms homotrimers and higher-order oligomers and it may also form heteromeric complexes with CTRP1. May be involved in kidney inflammation.

NCBI Gene ID

114904

Swiss Prot

Q9BXI9

Accession Number

37181873

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human CTRP6 (globular domain-less) .

Clonality

Monoclonal

Clone

256-E

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Innate Immunity, Obesity

Concentration

0.5 mg/ml

Buffer

Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG1, kappa

Specificity

Recognizes the N-terminal half of human CTRP6 full-length protein. Detects bands of ~16kDa and ~32kDa by Western blot.

Applications Notes

ELISA: (direct or indirect: 1:200-1:500) . Immunohistochemistry (paraffin sections) : 1:200. Western blot: (1:200-1:500 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature) . Optimal conditions should be determined individually for each application.