ST2 Antibody [ST33868]
Product Specifications
Background
The ST2 gene was originally identified as a gene induced by serum or oncogene expression in fibroblasts. The gene produces a shorter soluble secreted form (ST2) and a longer, transmembrane form (ST2L) by alternative splicing. Soluble ST2 has been shown to downregulate the expression of TLR1 and TLR4. ST2L negatively regulates TLR4 signaling and induces endotoxin tolerance, and enhances Th2 responses. IL-33 is the specific ligand for ST2L.
NCBI Gene ID
9173
Swiss Prot
Q01638
Accession Number
116242527
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human soluble ST2.
Clonality
Monoclonal
Clone
ST33868
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Concentration
1 mg/ml
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=36-046
Fragment
IgG1, kappa
Specificity
Recognizes human ST2.
Applications Notes
ELISA: (direct or indirect: 1:2,000-1:5,000) . Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature) . Optimal conditions should be determined individually for each application.
Symbol
IL1RL1
NCBI Official Name
Interleukin 1 receptor like 1
NCBI Organism
Homo sapiens
Other Product Names
Interleukin-1 Receptor-like 1; IL-1 Receptor-like 1; IL1RL1; IL-33 Receptor; Interleukin-33 Receptor
Tested Applications
ELISA, WB
Protein ID
Q01638
Physical Properties
Liquid
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