CD137L Antibody [41B436]
Product Specifications
Background
The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
NCBI Gene ID
8744
Swiss Prot
P41273
Accession Number
728739
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human CD137L extracellular domain.
Clonality
Monoclonal
Clone
41B436
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology
Concentration
1 mg/ml
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1, kappa
Specificity
Recognizes extracellular domain of human CD137L. Does not cross-react with mouse CD137L.
Applications Notes
ELISA: (direct or indirect: 1:500-1:5,000) . Flow Cytometry: (1:1,000) . Immunocytochemistry: (see reference Nr. 2) . Western blot: (1:2,000) . Optimal conditions should be determined individually for each application.
Symbol
TNFSF9
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 9
NCBI Organism
Homo sapiens
Other Product Names
4-1BBL; TNFSF9
Tested Applications
ELISA, Flow, ICC, WB
Protein ID
P41273
Physical Properties
Liquid
Frequently Asked Questions
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