CD137L Antibody [41B436]

Product Specifications

Background

The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.

NCBI Gene ID

8744

Swiss Prot

P41273

Accession Number

728739

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human CD137L extracellular domain.

Clonality

Monoclonal

Clone

41B436

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology

Concentration

1 mg/ml

Buffer

Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C.

Fragment

IgG1, kappa

Specificity

Recognizes extracellular domain of human CD137L. Does not cross-react with mouse CD137L.

Applications Notes

ELISA: (direct or indirect: 1:500-1:5,000) . Flow Cytometry: (1:1,000) . Immunocytochemistry: (see reference Nr. 2) . Western blot: (1:2,000) . Optimal conditions should be determined individually for each application.