NUDT15 Antibody

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity) . May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.

This NUDT15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the C-terminal region of human NUDT15.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Hori, M., et al. Free Radic. Biol. Med. 48 (9) :1197-1201 (2010) Yu, Y., et al. J. Biol. Chem. 284 (29) :19310-19320 (2009) Dunham, A., et al. Nature 428 (6982) :522-528 (2004) Cai, J.P., et al. Biochem. Biophys. Res. Commun. 305 (4) :1073-1077 (2003)

Probable 8-oxo-dGTP diphosphatase NUDT15, 8-oxo-dGTPase NUDT15,8-dihydro-8-oxoguanine-triphosphatase NUDT15, MutT homolog 2, MTH2, Nucleoside diphosphate-linked moiety X motif 15, Nudix motif 15, NUDT15, MTH2