PPM1L Antibody

Product Specifications

Background

PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg (2+) or Mn (2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]) .

NCBI Gene ID

151742

Swiss Prot

Q5SGD2

Accession Number

Q5SGD2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PPM1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the C-terminal region of human PPM1L.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Symbol

PPM1L

NCBI Official Name

Protein phosphatase 1L

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Thean, L.F., et al. Genes Chromosomes Cancer 49 (2) :99-106 (2010)

Background Reference 03

Trynka, G., et al. Gut 58 (8) :1078-1083 (2009)

Background Reference 04

Saito, S., et al. J. Biol. Chem. 283 (10) :6584-6593 (2008)

Other Product Names

Protein phosphatase 1L, Protein phosphatase 1-like, Protein phosphatase 2C isoform epsilon, PP2C-epsilon, PPM1L, PP2CE

Tested Applications

WB, IHC-P

Protein ID

74743437

Physical Properties

Liquid

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