TNFAIP8 Antibody

Product Specifications

Background

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

NCBI Gene ID

25816

Swiss Prot

O95379

Accession Number

O95379

Host

Rabbit

Reactivity

Human

Immunogen

This TNFAIP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human TNFAIP8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

23 kDa

Fragment

Rabbit Ig

Symbol

TNFAIP8

NCBI Official Name

Tumor necrosis factor alpha-induced protein 8

NCBI Organism

Homo sapiens

Background Reference 01

Dong, Q.Z., et al. Cancer Sci. 101 (6) :1562-1569 (2010)

Background Reference 02

Zhang, L.J., et al. J. Biol. Chem. 284 (10) :6156-6168 (2009)

Background Reference 03

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Background Reference 04

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

Other Product Names

Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-313, NF-kappa-B-inducible DED-containing protein, NDED, SCC-S2, TNF-induced protein GG2-1, TNFAIP8