ITIH5 Antibody

Product Specifications

Background

This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

80760

Swiss Prot

Q86UX2

Accession Number

Q86UX2

Host

Rabbit

Reactivity

Human

Immunogen

This ITIH5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 578-606 amino acids from the C-terminal region of human ITIH5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

105 kDa

Fragment

Rabbit Ig

Symbol

ITIH5

NCBI Official Name

Inter-alpha-trypsin inhibitor heavy chain H5

NCBI Organism

Homo sapiens

Background Reference 01

Pita, J.M., et al. Br. J. Cancer 101 (10) :1782-1791 (2009)

Background Reference 02

Veeck, J., et al. Pathologe 29 SUPPL 2, 338-346 (2008) :

Background Reference 03

Veeck, J., et al. Oncogene 27 (6) :865-876 (2008)

Background Reference 04

Hamm, A., et al. BMC Cancer 8, 25 (2008) :

Other Product Names

Inter-alpha-trypsin inhibitor heavy chain H5, ITI heavy chain H5, ITI-HC5, Inter-alpha-inhibitor heavy chain 5, ITIH5, KIAA1953

Tested Applications

WB, IHC-P

Protein ID

187609608

Physical Properties

Liquid

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