KRT80 Antibody

Product Specifications

Background

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.

NCBI Gene ID

144501

Swiss Prot

Q6KB66

Accession Number

Q6KB66

Host

Rabbit

Reactivity

Human

Immunogen

This KRT80 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human KRT80.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

51 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KRT80

NCBI Official Name

Keratin, type II cytoskeletal 80

NCBI Organism

Homo sapiens

Background Reference 01

Langbein, L., et al. J. Biol. Chem. 285 (47) :36909-36921 (2010)

Background Reference 02

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Background Reference 03

Schweizer, J., et al. J. Cell Biol. 174 (2) :169-174 (2006)

Background Reference 04

Rogers, M.A., et al. J. Invest. Dermatol. 124 (3) :536-544 (2005)

Other Product Names

Keratin, type II cytoskeletal 80, Cytokeratin-80, CK-80, Keratin-80, K80, Type-II keratin Kb20, KRT80, KB20

Tested Applications

Protein ID

166218808

Physical Properties

Liquid

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