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SYNE3 Antibody

Product Specifications

Background

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.

NCBI Gene ID

161176

Swiss Prot

Q6ZMZ3

Accession Number

Q6ZMZ3

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SYNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 852-880 amino acids from the C-terminal region of human SYNE3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=55-447

Calculated Molecular Weight

112 kDa

Fragment

Rabbit Ig

Symbol

SYNE3

NCBI Official Name

Nesprin-3

NCBI Organism

Homo sapiens

Background Reference 01

Nery, F.C., et al. J. Cell. Sci. 121 (PT 20), 3476-3486 (2008) :

Background Reference 02

Stewart-Hutchinson, P.J., et al. Exp. Cell Res. 314 (8) :1892-1905 (2008)

Background Reference 03

Wilhelmsen, K., et al. J. Cell Biol. 171 (5) :799-810 (2005)

Background Reference 04

Heilig, R., et al. Nature 421 (6923) :601-607 (2003)

Other Product Names

Nesprin-3, Nuclear envelope spectrin repeat protein 3, SYNE3, C14orf49

Tested Applications

WB, IHC-P

Protein ID

134035037

Physical Properties

Liquid

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