GNMT Antibody

Product Specifications

Background

Glycine N-methyltransferase catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells.

NCBI Gene ID

27232

Swiss Prot

Q14749

Accession Number

Q14749

Host

Rabbit

Reactivity

Human

Immunogen

This GNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-248 amino acids from the C-terminal region of human GNMT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GNMT

NCBI Official Name

Glycine N-methyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Augoustides-Savvopoulou, P., et al., J. Inherit. Metab. Dis. 26 (8) :745-759 (2003) . Tseng, T.L., et al., Cancer Res. 63 (3) :647-654 (2003) . Luka, Z., et al., Hum. Genet. 110 (1) :68-74 (2002) . Strausberg RL, et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) . Mudd, S.H., et al., J. Inherit. Metab. Dis. 24 (4) :448-464 (2001) .