TMLHE Antibody

Product Specifications

Background

This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants.

NCBI Gene ID

55217

Swiss Prot

Q9NVH6

Accession Number

Q9NVH6

Host

Rabbit

Reactivity

Human

Immunogen

This TMLHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the N-terminal region of human TMLHE.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TMLHE

NCBI Official Name

Trimethyllysine dioxygenase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Monfregola, J., et al. Gene 395 (1-2), 86-97 (2007) :

Background Reference 02

Monfregola, J., et al. J. Cell. Physiol. 204 (3) :839-847 (2005)

Background Reference 03

Vaz, F.M., et al. J. Biol. Chem. 276 (36) :33512-33517 (2001)

Background Reference 04

Rogner, U.C., et al. Genome Res. 6 (10) :922-934 (1996)

Other Product Names

Trimethyllysine dioxygenase, mitochondrial, Epsilon-trimethyllysine 2-oxoglutarate dioxygenase, Epsilon-trimethyllysine hydroxylase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, TML dioxygenase, TMLD, TMLHE, TMLH