EPAS1 Antibody

Product Specifications

Background

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

NCBI Gene ID

2034

Swiss Prot

Q99814

Accession Number

Q99814

Host

Rabbit

Reactivity

Human

Immunogen

This EPAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-150 amino acids from the N-terminal region of human EPAS1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

96 kDa

Fragment

Rabbit Ig

Symbol

EPAS1

NCBI Official Name

Endothelial PAS domain-containing protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Yi, X., et al. Science 329 (5987) :75-78 (2010)

Background Reference 03

Bougatef, F., et al. PLoS ONE (8), E12265 (2010) :

Background Reference 04

Hossein Ghaderian, S.M., et al. Pathology 42 (5) :446-453 (2010)

Other Product Names

Endothelial PAS domain-containing protein 1, EPAS-1, Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73, bHLHe73, HIF-1-alpha-like factor, HLF, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Member of PAS protein 2, PAS domain-containing protein 2, EPAS1, BHLHE73, HIF2A, MOP2, PASD2