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COL18A1 Antibody

Product Specifications

Background

COL18A1 is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.

NCBI Gene ID

80781

Swiss Prot

P39060

Accession Number

P39060

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This COL18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1311-1339 amino acids from the Central region of human COL18A1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

178 kDa

Fragment

Rabbit Ig

Symbol

COL18A1

NCBI Official Name

Collagen alpha-1 (XVIII) chain

NCBI Organism

Homo sapiens

Background Reference 01

Hamano, Y., et al. J. Am. Soc. Nephrol. 21 (9) :1445-1455 (2010)

Background Reference 02

Roberts, K.E., et al. Gastroenterology 139 (1) :130-139 (2010)

Background Reference 03

Lee, K.S., et al. Tumour Biol. 31 (3) :165-170 (2010)

Background Reference 04

Faye, C., et al. Biochem. J. 427 (3) :467-475 (2010)

Other Product Names

Collagen alpha-1 (XVIII) chain, Endostatin, COL18A1

Tested Applications

WB, IHC-P

Protein ID

215274264

Physical Properties

Liquid

Frequently Asked Questions

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