B4GALT6 Antibody

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis.

This B4GALT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-346 amino acids from the C-terminal region of human B4GALT6.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (22) :9004-9009 (2009) Gevaert, K., et al. Nat. Biotechnol. 21 (5) :566-569 (2003) Fan, Y., et al. DNA Seq. 13 (1) :1-8 (2002) Amado, M., et al. Biochim. Biophys. Acta 1473 (1) :35-53 (1999) Takizawa, M., et al. Biochim. Biophys. Acta 1438 (2) :301-304 (1999)

Beta-1,4-galactosyltransferase 6, Beta-1,4-GalTase 6, Beta4Gal-T6, b4Gal-T6, 241-, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6, Glucosylceramide beta-1,4-galactosyltransferase, Lactosylceramide synthase, LacCer synthase, UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase, B4GALT6