UPF2 Antibody
Product Specifications
Background
UPF2 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p.
NCBI Gene ID
26019
Swiss Prot
Q9HAU5
Accession Number
Q9HAU5
Host
Rabbit
Reactivity
Human
Immunogen
This UPF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 630-656 amino acids from the Central region of human UPF2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
148 kDa
Fragment
Rabbit Ig
Symbol
UPF2
NCBI Official Name
Regulator of nonsense transcripts 2
NCBI Organism
Homo sapiens
Background Reference 01
Clerici, M., et al. EMBO J. 28 (15) :2293-2306 (2009)
Background Reference 02
Cronin, S., et al. Eur. J. Hum. Genet. 17 (2) :213-218 (2009)
Background Reference 03
Woeller, C.F., et al. EMBO Rep. 9 (5) :446-451 (2008)
Background Reference 04
Chamieh, H., et al. Nat. Struct. Mol. Biol. 15 (1) :85-93 (2008)
Other Product Names
Regulator of nonsense transcripts 2, Nonsense mRNA reducing factor 2, Up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2
Tested Applications
WB, Flow
Protein ID
60390647
Physical Properties
Liquid
Frequently Asked Questions
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