ACF Antibody
Product Specifications
Background
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.
NCBI Gene ID
29974
Swiss Prot
Q9NQ94
Accession Number
Q9NQ94
Host
Rabbit
Reactivity
Human
Immunogen
This ACF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-423 amino acids from the C-terminal region of human ACF.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Symbol
A1CF
NCBI Official Name
APOBEC1 complementation factor
NCBI Organism
Homo sapiens
Background Reference 01
Galloway, C.A., et al. Biochem. Biophys. Res. Commun. 391 (1) :659-663 (2010)
Background Reference 02
Blanc, V., et al. Mol. Cell. Biol. 25 (16) :7260-7269 (2005)
Background Reference 03
Deloukas, P., et al. Nature 429 (6990) :375-381 (2004)
Background Reference 04
Xie, K., et al. Proc. Natl. Acad. Sci. U.S.A. 101 (21) :8114-8119 (2004)
Other Product Names
APOBEC1 complementation factor, APOBEC1-stimulating protein, A1CF, ACF, ASP {ECO:0000312|EMBL:CAB947541}
Tested Applications
WB, IHC-P, Flow
Protein ID
74761651
Physical Properties
Liquid
Frequently Asked Questions
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