SCN1B Antibody

Product Specifications

Background

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

6324

Swiss Prot

Q07699

Accession Number

Q07699

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SCN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Rabbit, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

25 kDa

Fragment

Rabbit Ig

Symbol

SCN1B

NCBI Official Name

Sodium channel subunit beta-1

NCBI Organism

Homo sapiens

Background Reference 01

Grover, S., et al. Pharmacogenomics 11 (7) :927-941 (2010)

Background Reference 02

Tan, B.H., et al. Heart Rhythm 7 (6) :771-778 (2010)

Background Reference 03

Casini, S., et al. Cardiovasc. Res. 85 (4) :691-700 (2010)

Background Reference 04

Ogawa, R., et al. IntClin Pharmacol Ther 48 (2) :109-119 (2010)

Other Product Names

Sodium channel subunit beta-1, SCN1B

Tested Applications

WB, IHC-P, Flow

Protein ID

1705868

Physical Properties

Liquid

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