Mouse Dnmt3L Antibody

Product Specifications

Background

MDnmt3L (DNA methyltransferase 3L) does not appear to be catalytically active due to loss of the critical active site residues. It may function not directly as a DNA methyltransferase but rather as a regulator of methylation at imprinted loci. It is required specifically for the establishment of genomic imprints but is dispensable for their propagation. It is essential for the de novo methylation of single-copy DNA sequences. The protein is well-express in testis, thymus, ovary, and heart. mDnmt3L, which belongs to the 5-cytosine methyltransferase family, contains 1 ADD-type zinc finger.

NCBI Gene ID

54427

Swiss Prot

Q9CWR8

Accession Number

Q9CWR8

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Mouse Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-421 amino acids from mouse Dnmt3L.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Dnmt3l

NCBI Official Name

DNA (cytosine-5) -methyltransferase 3-like

NCBI Organism

Mus musculus

Background Reference 01

Okazaki, Y., et al., Nature 420 (6915) :563-573 (2002) .

Background Reference 02

Bourc'his, D., et al., Science 294 (5551) :2536-2539 (2001) .

Background Reference 03

Aapola, U., et al., Cytogenet. Cell Genet. 92 (1-2), 122-126 (2001) .

Other Product Names

DNA (cytosine-5) -methyltransferase 3-like, Dnmt3l

Tested Applications

Physical Properties

Liquid

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