INPP5B Antibody

Product Specifications

Background

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases) . INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].

NCBI Gene ID

3633

Swiss Prot

P32019

Accession Number

P32019

Host

Rabbit

Reactivity

Human

Immunogen

This INPP5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 950-979 amino acids from the C-terminal region of human INPP5B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

113 kDa

Fragment

Rabbit Ig

Symbol

INPP5B

NCBI Official Name

Type II inositol 1,4,5-trisphosphate 5-phosphatase

NCBI Organism

Homo sapiens

Background Reference 01

Coon, B.G., et al. Hum. Mol. Genet. 18 (23) :4478-4491 (2009)

Background Reference 02

Mao, Y., et al. EMBO J. 28 (13) :1831-1842 (2009)

Background Reference 03

Williams, C., et al. J. Cell. Sci. 120 (PT 22), 3941-3951 (2007) :

Background Reference 04

Speed, C.J., et al. Eur. J. Biochem. 234 (1) :216-224 (1995)

Other Product Names

Type II inositol 1,5-trisphosphate 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, 5PTase, INPP5B, OCRL2

Tested Applications

WB, IHC-P, Flow

Protein ID

281185510

Physical Properties

Liquid

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