Von Willebrand Factor Antibody [SPM577]
Product Specifications
Background
Von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi's sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.
NCBI Gene ID
7450
Swiss Prot
P04275
Host
Mouse
Reactivity
Human
Immunogen
A partial recombinant human protein was used as the immunogen for this anti-von Willebrand Factor antibody.
Clonality
Monoclonal
Clone
SPM577
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Stem Cell
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=34-183
Fragment
IgG1, kappa
Applications Notes
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Symbol
VWF
NCBI Official Name
Von Willebrand factor
NCBI Organism
Homo sapiens
Other Product Names
VWF, Coagulation factor VIII VWF, F8VWF, VWD, Von Willebrand factor
Tested Applications
Flow, IF, WB, IP, IHC
Physical Properties
Liquid
Curated Selection
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