TOP2A Antibody [TPM2A-1]
Product Specifications
Background
This mAb recognizes a 170kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.
NCBI Gene ID
7153
Swiss Prot
P11388
Host
Mouse
Reactivity
Human
Immunogen
Human partial recombinant protein was used as the immunogen for this TOP2A antibody.
Clonality
Monoclonal
Clone
TPM2A-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG2b, kappa
Applications Notes
1. Staining of FFPE tissue requires boiling sections in 10mM citrate buffer, pH6, for 10-20 min followed by cooling at RT for 20 min.
Symbol
TOP2A
NCBI Official Name
Topoisomerase (DNA) II alpha 170kDa
NCBI Organism
Homo sapiens
Other Product Names
DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2
Tested Applications
WB, Flow, IF, IHC
Physical Properties
Liquid
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