FLI1 Antibody [FLVI1-1]
Product Specifications
Background
Friend leukemia integration 1 is a member of the ETS family of DNA binding transcription factors that is involved in cellular proliferation and tumorigenesis. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing's Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t (11;22) (q24; q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi's Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
NCBI Gene ID
2313
Swiss Prot
Q01543
Host
Mouse
Reactivity
Human
Immunogen
Human partial recombinant protein (amino acids 107-216) was used as the immunogen for this FLI1 antibody.
Clonality
Monoclonal
Clone
FLVI1-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG
Symbol
FLI1
NCBI Official Name
Fli-1 proto-oncogene, ETS transcription factor
NCBI Organism
Homo sapiens
Other Product Names
Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB, FLI1
Tested Applications
WB, Flow, IF
Physical Properties
Liquid
Frequently Asked Questions
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